ceesdekker.net - An Overview
ceesdekker.net - An Overview
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‘Sure, that may be about proper. I try to find a physical comprehension of Organic methods in a very bottom-up way. I believe you could possibly distinguish three strains of analysis in my team in the mean time. The 1st considerations chromosome structure: How can you have a metre-extended DNA polymer folded and organised in this kind of microscopic mobile? We've designed visualisation techniques that enable us to review how, for example, SMC proteins loop DNA (movie on Youtube) so that you can Construct up chromosomes.
But how do morality, the dignity from the individual, my practical experience on the which means of life, abide by through the movement of atoms? A purely naturalistic standpoint fails listed here; a Christian point of view, I believe, is a way more realistic method to interpret these components of actuality.’
Multicolor imaging in the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins
Considering the fact that 2000, Dekker has shifted the primary concentration of his work in direction of biophysics where he reports the Attributes of single biomolecules and cells using the equipment of nanotechnology. This alteration of field was driven by his fascination to the amazing performing of biological molecular structures, along with because of the long-term viewpoint that lots of appealing discoveries is usually anticipated With this industry.[five] Present-day strains of study in his biophysics group are within the regions of:[6]
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SMC complexes can pass physical roadblocks larger than their ring dimensions, indicating a nontopological mechanism for DNA loop extrusion
What distinguishes biology from chemistry is always that these components together make up a residing process. The secret of reported life, I believe, lies during the interactions, the interplay of These molecules. The massive issue with regard to the origin of life remains unanswered. How did we ever evolve from straightforward molecules into your really sophisticated units we see currently? We do not know. I need to work on These types of massive, open up inquiries.’
Circulation-driven rotary motors including windmills and water wheels drive purposeful procedures in human Culture. Despite the fact that examples of this kind of rotary motors also function prominently in cell biology, their artificial development with the nanoscale has remained demanding. Listed here we show flow-pushed rotary movement of a self-structured DNA nanostructure that is definitely docked onto a nanopore in a thin solid-point out membrane. An elastic DNA bundle self-assembles into a chiral conformation upon phoretic docking on to the sound-state nanopore, and subsequently shows a sustained unidirectional rotary movement of up to 20 rev s−one.
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‘The fantastically subtle way in which features in character perform by no means ceases to amaze me. If we solve the puzzle of how everyday living arrived into becoming, I expect that my amazement within the complexity of development can have elevated and with it my awe for the greatness with the Creator.’
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Nanoscientist Cees Dekker is really an amiable and flamboyant male who appears A lot younger when compared to the sixty two a long time he really is – fashionable Eyeglasses, psychedelic shirt, participating smile – but not one to squander time. He will take his time, but no more than vital.
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At last, I'll briefly sketch many of our ideas to discover the creating of synthetic cells, exclusively our 1st techniques to ascertain artificial cell division.