ceesdekker No Further a Mystery

ceesdekker No Further a Mystery

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Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits incorporate:

You regularly get entangled in discussions about science and religion. You've got also composed several textbooks on the subject. Don’t you believe eventually we will know all the things and that God’s role is going to be more than?

[Laughs] ‘It had been undoubtedly a fantastic threat! At time, I was properly informed that it could go Erroneous Which I could turn into a lot less effective, but I just ignored that. Curiosity has normally been my strongest driving drive. And by chance all of it worked out.’

Considering that 2000, Dekker has shifted the primary aim of his get the job done in the direction of biophysics where he reports the properties of one biomolecules and cells utilizing the resources of nanotechnology. This variation of industry was driven by his fascination for your impressive operating of Organic molecular buildings, in addition to with the very long-time period perspective that many intriguing discoveries might be envisioned in this field.[5] Present traces of investigation in his biophysics group are while in the regions of:[six]

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping

Experimental stage diagram of negatively supercoiled DNA calculated by magnetic tweezers and fluorescence,

What distinguishes biology from chemistry is the fact these components jointly make up a living process. The secret of https://www.ceesdekker.net claimed existence, I do think, lies inside the interactions, the interaction of These molecules. The massive issue about the origin of daily life remains unanswered. How did we ever evolve from uncomplicated molecules into the really complex techniques we see now? We have no idea. I would like to operate on These types of large, open thoughts.’

Nanopores represent a sublime and versatile tool to evaluate one molecules. We investigate novel detection modes with solid-state nanopores in addition to numerous methods to measure proteins with nanopores. Projects encompass the subsequent:

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There was a single dilemma while — we didn't notice any measurable electrical conduction from The one polymer molecules. We concluded that at The one-molecule amount, conducting polymers were really not this kind of excellent conductors, which was relatively disappointing. We As a result broadened our watch to test to search out additional promising molecules.

An built-in microfluidic System for quantifying drug permeation across biomimetic vesicle membranes

1999, initially measurement from the wavefunction of one molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes

2005, discovery with the mechanism of DNA uncoiling by topoisomerase enzymes; discovery of prolonged-range conformational alterations in Mre11/DNA repair complexes; and 1st drive measurements on the DNA molecule in a very nanopore

 Lastly, I will briefly sketch a number of our Concepts to examine the setting up of artificial cells, specifically our initial actions to establish synthetic cell division.